Eosinophils on trial

Active on Eosinophils : Potential Roles in

p resendy, the eosinophil is recognized as a proinflammatory granulocyte imphcated in protection against parasitic infection and hkely plays a major rote in allergic diseases, such as bronchial asthma, allergic rhinitis, and atopic dermatitis (1). The eosinophil is a rich source of cytotoxic proteins, hpid mediators, oxygen metabohtes, and cytokines: all with the potential to induce pathophysio...

Leukotriene generation by eosinophils

Horse eosinophils purified to greater than 98% generated slow reacting substance (SRS) when incubated with the calcium ionophore A23187. On a per cell basis, eosinophils generated four to five times the SRS produced by similarly treated horse neutrophils. Eosinophil SRS production was inhibited by 5,8,11,14-eicosatetraynoic acid and augmented by indomethacin and arachidonic acid, suggesting tha...

Neurotoxicity of human eosinophils.

Eosinophils contain a substance that is neurotoxic when injected intracerebrally or intrathecally into laboratory animals-an effect known as the "Gordon phenomenon." We found neurotoxic activity in eosinophils from three patients with eosinophilic syndromes by injecting cell preparations into rabbits and guinea pigs. These animals developed a syndrome of muscular rigidity and ataxia, progressin...

Phagocytosis by human eosinophils.

E OSINOPHILS were first recognized as a distinctive type of granulocyte over 100 years ago,’ and were observed to be capable of phagocytosis by Mesnil in 1895.2 Despite a voluminous literature on the morphology and functions of these cells, their precise role in normal man and in various diseases remains unclear. In general, eosinophils from higher mammals resemble other granulocytic cells in t...

Eosinophils Mediate Protective Immunity